There is a history of permanent settlement on Flitwick Moor as early as 4000 BC, but the village gained its greatest importance when the Romans built a road through Flitwick linking Ermine Street and Watling Street. The current Windmill Road follows the route of the Roman road. The Saxons eventually ousted the Romano-British inhabitants and established farms near the sites now occupied by Flitwick Manor and Flitwick Mill. The Saxons also built a church at Priestley (“priest’s meadow”), near the manor house.

Flitwick was mentioned in the Doomsday Book, when it was given to the Norman Lord, William de Lovet. In 1150 the parish church of St Peter and St Paul, and the mill were gifted to Dunstable Priory by the Lord of Flitwick. The Priory held the church until the Dissolution of the Monasteries.

Medical Practice in this area can be traced back to visiting surgeons from Toddington and Clophill in the 16th Century. This practice originated in Church Street, Ampthill in 1760. At the end of the 19th Century the small village of Flitwick expanded and the single-handed practice became a partnership. Gradually more doctors began practicing in the area. By 1988 there were 10 doctors in partnership in Ampthill and Flitwick. In the spring of 1989 this very large group divided, for administrative reasons, creating four doctor partnerships in Ampthill and six in the new Flitwick surgery, which was designed and financed by the doctors in 1982.